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(34034086) (b) Contrast enhancement: lumbar puncture The primary indication is typically the exclusion of meningitis or encephalitis

Subcutaneous injections are also very effective, but just a bit slower entering the bloodstream than intravenous and intramuscular

Micheletti A, Rossi R, Rufini S

Effect of berberine phytosome on reproductive, dermatologic, and metabolic characteristics in women with polycystic ovary syndrome: a controlled, randomized, multi-centric, open-label clinical trial

This paradigm is obviously particularly important, as it prevents the rapid release of a large amount of substance into the bloodstream with the detrimental consequences already mentioned, but it is equally important to develop formulations that enable the controlled release of the active ingredient from these deposits as a way to extend the duration of the expected effect

doi: 10.1016/j.pbb.2012.04.004 68 GriswoldA