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In addition, the Trx system can interact also with the peroxiredoxins (Prxs), which constitute a novel family of thiol-specific peroxidases that rely on Trx as the hydrogen donor for the reduction of hydrogen peroxides and lipid-hydroperoxides (16)

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Unlike many peptide ligands that possess well-characterized receptor targets and signaling pathways, DSIP remains associated with an incompletely defined mechanism of action

In addition, miR-100 was shown to target directly the IGF1R and to inhibit PI3K/AKT and MAPK/ERK pathways

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The anti-apoptotic effects of rhGH are validated in irradiated BALB/c mice treated for 35 days irradiation, and rhGH treatment significantly restores hematologic and immune (Chen et al., 2010)