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Description
Following activation of glutamate receptors, mitochondrial respiratory chain defects along with calcium overload and ROS accumulation seem to be the major routes that are induced, allowing the stimulation of apoptosis (91,92)
References Townsend DM, Tew KD, Tapiero H
& Stern, M
Mitchell EM
However, for the older regimens still in use, the clinical trials that led to their use did not typically report detailed information on side effects like newer therapies do now
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