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Endothelial dysfunction (ED) occurs as a result of the impairment of EC regulatory functions and is linked to the development of many diseases including atherosclerosis, hypertension, liver diseases, diabetes, and even COVID-19 [11, 16,17,18,19,20]

The sustained oxidative stress status in KO livers was paralleled by increased levels of transcription factor NRF2 in the nucleus (Fig

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