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In case of autoimmune components, auto-antibodies directed at fetal brain proteins might cause BBB damage (Zimmerman et al., 2007)

ACSL4 is widely expressed in brain tissue, especially in the hippocampal CA1 region, and the expression of ACSL4 is gradually increased during cerebral ischemia (Kassan et al., 2013

Katturajan R, Vijayalakshmi S, Rasool M, Prince SE (2021) Molecular toxicity of methotrexate in rheumatoid arthritis treatment: a novel perspective and therapeutic implications

Glutathione is composed of three amino acids, cysteine, glycine, and glutamine

Wang X, Chen Z, Xu J, Tang S, An N, Jiang L, et al

Zawilska JB, Skene DJ, Arendt J