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[DOI] [PMC free article] [PubMed] [Google Scholar] 876.Dharmajaya R., Sari D.K

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Activity at mu and delta receptors mediates classic opioid effects (e.g., analgesia, euphoria, sedation) while drugs that mimic the endogenous ligand for kappa receptors exert an opposite pharmacologic profile (e.g., increased pain sensitivity, dysphoria)