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found that ferroptosis occurred in testicular tissue of STZ-induced diabetic mice and in high glucose-treated GC-2 testicular glial cells, both of which showed iron accumulation, increased MDA levels, decreased GSH levels, and down-regulated GPX4, FTL, and SLC7A1 [63]

doi: Mendoza-Vargas L, Sevilla-Fuentes S, Bautista-Becerril B, et al

Access this article Similar content being viewed by others Abbreviations [Ca 2+ ] c : Intracellular free Ca 2+ concentration CM-H 2 DCFDA: 5-(and-6)-Chloromethyl-2,7-dichlorodihydrofluorescein diacetate, acetyl ester ER: Endoplasmic reticulum Fura-2-AM: Fura-2-acetoxymethyl ester GSH: Reduced glutathione GSSG: Oxidized glutathione HBSS: Hanks balanced salts HPSCs: Human pancreatic stellate cells H 2 O 2 : Hydrogen peroxide ROS: Reactive oxygen species RPSCs: Rat pancreatic stellate cells SERCA: Sarcoendoplasmic reticulum Ca 2+ -ATPase Tps: Thapsigargin -sma: Alpha-smooth muscle actin References Acua-Castroviejo D, Escames G, Venegas C, Daz-Casado ME, Lima-Cabello E, Lpez LC, Rosales-Corral S, Tan DX, Reiter RJ (2014) Extrapineal melatonin: sources, regulation, and potential functions

In this regard, the intranasal route is a promising delivery method to obtain greater efficacy in maintaining optimal drug concentrations in the brain compared to parenteral injections [17-20]

Patients with IPF often present with progressive dyspnea, and lung function continues to deteriorate

DNA methylation patterns in ALS patients reveal significant deviations involving multiple genes and biological pathways (145, 146)