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Dan Wool, NMD Arizona-licensed Naturopathic Physician and Gastroenterology Specialist Updated: February 26, 2026 Summary (tl;dr): What AOD-9604 Is and How It Works: AOD-9604 is a synthetic 16-amino acid fragment of human growth hormone (hGH) specifically amino acids 176191 engineered to target fat metabolism

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The preservation of normal glucose-insulin dynamics with AOD-9604 is important for appetite neutrality, as blood sugar fluctuations and insulin spikes are major drivers of hunger and cravings

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Research Methods Literature Search Search Strategy A literature search was performed on August 26, 2012, using Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid Embase, EBSCO Cumulative Index to Nursing & Allied Health Literature (CINAHL), the Wiley Cochrane Library, and the Centre for Reviews and Dissemination database, for studies published from January 1, 2002, until August 26, 2012