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Activation of this pathway results in protein synthesis, hypertrophy and inhibition of the key ubiquitin ligase atrogin-1 by inactivating Foxo factors[82], IGF-IR also phosphorylates Shc, which subsequently activates the RAS/Raf/MEK pathway leading to cell proliferation and mitogenesis[2]

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Typically, the kidney uses very little glutamine

doi: 10.1053/j.gastro.2010.08.006

Li 2 1 Occupational Therapy Dept., 2 Dept

Autophagy degrades and recycles damaged cellular components and plays a key role in the metabolic reprogramming of cells, helping them cope with adverse environmental stimuli [21]