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[7] Anatomical connections between brain areas such as the amygdala, hippocampus, prefrontal cortex and hypothalamus facilitate activation of the HPA axis

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There is evidence that VGEF can be particularly involved in schizophrenia [291,292,293,294], given abnormal vascularization and VEGF acting as an angiogenic and neurotrophic factor involved in the regulation of cerebral blood volume and flow in schizophrenia [294]