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It's the right choice for dogs with significant liver burden, long-term medication exposure, or elevated liver panels
Serious but rare reactions: Difficulty breathing or tightness in the chest due to hypersensitivity (extremely rare)
Significant inter-study heterogeneity was observed (I 2 =96%
E.et al (2022)
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Natural compounds like midazolam, vitamin B12, metformin, Cangrelor, and hesperidin have also shown anti-inflammatory effects in preclinical MIRI models, often by modulating macrophage polarization or inhibiting inflammatory pathways like NF-B (Xu et al., 2024)
