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Description

Having demonstrated success in preclinical assessments, they are now undergoing clinical investigations for glaucoma (NCT01544192

The elimination of senescent astrocytes using senolytics led to marked inhibition of glioma growth and prolonged survival in mice ( Targeting SASP also might strengthen immune responses

SNS overstimulation activates lymphoid tissues (e.g., the spleen and bone marrow), releasing NEs to mobilize monocytes and neutrophils, which produce proinflammatory cytokines (e.g., IL-6 and TNF-)

Further mechanistic studies revealed that JuB treatment upregulated total Nrf2 levels, promoted its nuclear translocation, increased the expression of HO-1 and NQO-1, and inhibited the activation of the STING pathway induced by APAP