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However, further experimental studies are required to substantiate the mechanism by which topiramate modulates these pathways and to confirm its efficacy in treating migraines
IGF-1 has been reported to be useful in the screening of GHD in some studies 3,4,5,6,7 but not in others 1,8

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For example, CCK1R-activated G q signaling is required for insulin secretion under low-glucose conditions, whereas G s signaling contributes more strongly to insulin secretion under high-glucose conditions 34

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