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[PubMed] [Google Scholar] 103.Won H.R., Lee G.H., Kim J.H., Lee S.H., Kwon S.Y., Baek S.K., Ryu C.H., Lee S.J., Park I.S., Shin S.C., et al

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8 The mechanisms of APAP-induced cell death, which apply to both animals and humans, include the formation of the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI) by cytochrome P450 2E1 (Cyp2E1), depletion of hepatic GSH, and protein adduct formation, primarily in mitochondria

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