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MPTP and Parkinson MPTP is a widely used neurotoxicant, known for the induction of Parkinson-like symptoms such as bradikinesia, movement disorders, -synuclein bodies, mitochondrial abnormalities, sustained inflammation in the substantia nigra and activation of the microglia [6,10,15, 79-80]

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Thus, measurement of blood 8-OHdG levels in PD patients exhibits possible importance for researching the connection between oxidative stress and PD

Wang X, Zhou Y, Min J, Wang F

Briefly, metabolites in plasma (100 L) were extracted with 90% methanol (900 L), and proteins were precipitated at -20 C for 2 h, followed by centrifugation for 10 min at 4000 rpm at 4 C

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