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Moreover, studies in pigs have shown that the combined inhibition of PKC and tyrosine kinases abolishes the protective effects of IPC, suggesting that Src-related pathways are required for full cardioprotection [218]

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The current challenge is to understand the temporal and spatial interactions among these cell death pathways and to identify context-specific targets that can be safely and effectively modulated in patients

10.1039/D3FO02330C 114

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[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Wang Y., An R., Umanah G.K., Park H., Nambiar K., Eacker S.M., Kim B., Bao L., Harraz M.M., Chang C., Chen R., Wang J.E., Kam T.I., Jeong J.S., Xie Z., Neifert S., Qian J., Andrabi S.A., Blackshaw S., Zhu H., Song H., Ming G.L., Dawson V.L., Dawson T.M