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The negative effect may be attributed to the fact that VEGF also has the potential to stimulate the expression of matrix metalloproteinases (MMPs) and inhibit the expression of tissue inhibitors of metalloproteinases (TIMPs) in endothelial cells and fibroblasts (Pufe et al., 2005

Furthermore, potential stem cell niches have been identified in the outer AF regions and adjacent to the epiphyseal plate across mammalian species [38]

I will also start doing eccentric loading of the extensor muscles using flex bar after the first week of injections