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( In the treatment of hypertension, quercetin can reduce hypertension induced aortic remodeling, oxidative stress, and MMP-2 activity ( In a clinical study of quercetin in the treatment of grade 2 hypertension, it was found that quercetin can significantly reduce the levels of nitric oxide, CRP, IL-1, and lipid profile in patients' peripheral blood ( Another randomized, double-blind, crossover clinical study found that 41 hypertensive patients had a significant decrease in blood pressure after 28 days of continuous administration of 730 mg quercetin, while the measured oxidative stress index in plasma and urine remained unchanged, which was contrary to previous animal experimental studies (Table 5)

Confocal microscopy The cell samples were fixed with 4% paraformaldehyde for 30 min, permeabilized with 0.1% Triton X-100 for 3 min and blocked with 3% BSA in PBS for 15 min at room temperature

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