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Likewise, several other chemotherapeutic agents, such as platinum complexes (e.g., cisplatin) [194] and sorafenib [195], enhance mitochondrial ROS production or hinder the antioxidant system, thereby causing heightened ROS levels within cancer cells

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Among the cysteine residues in Keap1, Cys-151, Cys-273, and Cys-288 are sensor sites that are particularly active for reacting with potential Nrf2 activators 53,54

Firstly, the relatively low-baseline CRP concentrations in study participants and the lack of tangible effects of methotrexate on the pro-inflammatory cytokines, IL-1 and IL-6, in CIRT suggests that further studies should focus on patients with significant residual inflammatory risk, that is, higher baseline CRP, IL-1 and IL-6 concentrations