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This specialized structure is primarily composed of endothelial cells (ECs) of blood vessels, which are tightly connected through paracellular tight junctions (TJs) and adherens junctions (AJs) that limit the uncontrolled passage of substances [68]

Both excessive and insufficient GC signaling may disturb BDNF expression and related neuroplastic processes in the hippocampus (Suri and Vaidya, 2013)

Further mechanistic investigations demonstrated that VSEE enhances the amounts of Wnt3a and LRP-5 proteins, thus stabilizing -catenin

Journal of Pioneering Medical Sciences

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Moreover, the study suggests that other S1P receptor modulators on the market, like Mayzent, Zeposia, and Ponvory, might also influence this CNS mechanism