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Ch5 ( KCNN2 , MB1 )

Eveleigh ER, Coneyworth L, Welham SJM

4-Hydroxythalidomide based PROTACs By exploiting the reactivity of the phenolic group of 4-hydroxythalidomide, its direct alkylation allows the synthesis of diverse and versatile starting building blocks for subsequent incorporation into the construction of cereblon-based PROTACs, e.g., via amidation, alkylation or click-chemistry reactions 97,110,111,112

To validate the role of SET7/9 in this process, the authors performed knockdown experiments using short hairpin RNA (shRNA) targeting SET7/9 (50)

doi: 10.3390/md21090475
The ability to target only a subset of ghrelin receptors is a desirable goal that would hopefully minimize side effects and maximize treatment
