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All statistical analyses were conducted using EZR (Saitama Medical Center, Jichi Medical University, Saitama, Japan), which serves as a graphical user interface for R (The R Foundation for Statistical Computing, Vienna, Austria) ( 3 Results 3.1 Locomotor function and pain hypersensitivity to mechanical and thermal stimulation In the mouse model of contusion SCI, hindlimb motor function deteriorated until reaching a stable level 4 weeks after injury, followed by some improvement thereafter (Figure 2A)

injections initially to rapidly replenish stores

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253 Genetic variations that affect the synthesis or degradation of ECM components can alter the mechanical properties of the ACL, influencing its ability to withstand mechanical stress

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