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Description
(2) Liu JR, Deng ZH, Zhu XJ, Zeng YR, Guan XX, Li JH
E., Hotamisligil G
Research shows that NNMT overexpression in adipose tissue creates a metabolic environment that favors lipid accumulation by depleting the very cofactors needed for efficient fatty acid oxidation
Because they mimic natural biological processes, they are often well-tolerated when used therapeutically
No human clinical trials have completed as of 2026
What the evidence really shows This is the key part: when AOD-9604 was tested in human weight-loss trials, the results largely did NOT show a strong effect
