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The metabolites were then analyzed using a Dionex Ultimate 3000 UPLC system coupled to a TSQ Quantiva Ultra triple-quadrupole mass spectrometer (Thermo Fisher, CA) equipped with a heated electrospray ionization (HESI) probe

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In addition, a study has shown that AS, as an dopant to DHB matrix, drastically enhances the quantitative detection of hydrophilic quaternary ammonium compounds (QACs) by MALDI-MS and MALDI-IMS, overcoming inherent ion suppression for these bioactive metabolites (ref )

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