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Individuals with Lebers disease (a hereditary optic nerve condition) should not receive high-dose B12

At 12 months, 71% of the patients in the TrA group experienced relapse of disease, while only 31% of the patients in the PRP group had a relapse

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Yet, the short duration of the study did not permit a conclusion on whether the lowering of homocysteine through B-vitamin supplementation could have long-term benefits on bone strength and fracture risk (119)