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Shyam Biswal and colleagues have reported the generation of an Nrf2-floxed mouse [490] that will allow the tissue-specific roles of the transcription factor to be investigated

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DOI: 10.1002/ptr.5018, Kamgar, E., Kaykhaii, M., & Zembrzuska, J
J Neurochem 96:12891300 Rebrin I, Sohal RS (2008) Pro-oxidant shift in glutathione redox state during aging

IGF-1 activates the Akt pathway, which is a downstream activator of mTOR, both of which are the master regulators of cellular growth and inhibitors of programmed cell death in the body

In addition, some pre-clinical/clinical gene therapy studies based on allotopic expression offer promising approaches for LHON [86, 87]
