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Water retention: Temporary mild edema has been reported in IGF-1 interventions due to cell hydration effects

Stentz NC, Koelper N, Barnhart KT, Sammel MD, Senapati S

Total fat reduction over the full 12 weeks often ranges from 6 to 12 pounds for individuals maintaining reasonable nutrition, with some users reporting higher losses when combining the protocol with structured caloric deficits

The FDA cited three concerns: potential immunogenicity (the peptide could trigger immune reactions), manufacturing impurity risks (synthetic peptides can contain truncated sequences and other contaminants), and a lack of human safety data sufficient to evaluate risk

Linus Pauling Institute Oregon State University Updated in February 2007 by: Victoria J

Biol Reprod (2004) 70(2):51822