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Since it is well known that GSH depletion leads to the upregulation of antioxidant genes, many of which are under Nrf2 control and, that in several types of tumors, Nrf2 is constitutively activated [122, 123], a new and indirect approach for cancer therapy may be used to modulate the Nrf2-ARE pathway

The complex also exhibits redox-regulating and antioxidant activity, suppressing free radicalmediated damage while broadly impacting gene expression patterns linked to regeneration and cellular protection

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Since exercise training can modify the number and cargo of extracellular vesicles which could partly mediate exercises benefits for the cardiovascular health, extracellular vesicle-based therapies prompt further investigation

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There is also a risk that, because it promotes blood vessel generation, it might also speed the growth of tumors, if the user happens to already have one