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Encapsulation of curcumin in a pluronic block copolymer demonstrated a slow and sustained release of curcumin and showed anticancer activity comparable with free curcumin (Sahu et al., 2010)

Zoccali C, Curatola G, Panuccio V, Tripepi R, Pizzini P, Versace M,

1, 5, 6, 7 Each successive regimen achieves a less durable response, suggesting emergence of a resistant phenotype and therefore MM remains largely incurable

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In experimental studies, AOD-9604 has been observed to stimulate fat oxidation , increase energy expenditure , and reduce adipose tissue accumulation through activation of beta-adrenergic lipolytic pathways

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