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The main supply of cobalamin comes from animal resources such as liver, kidney, meat, egg, and milk derivatives

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There was a significant improvement in the median MMSE score in the intervention group with increase in MMSE by 2 points at 6-8 weeks and 3 points at 12 weeks (p value 0.009 and 0.003 by Mann Whitney test)

In 2003, the famous Ralph Carmel wrote in the New England Journal of Medicine: The administration of folic acid can mask the megaloblastic anaemia caused by cobalamin deficiency

Finally, both cyano- and methyl-cobalamin supplementation to conventional C57BL/6J mice at 30 and 120 g/day similarly increased IL-12/23p40 levels in the colon

If you are also low in iron, B12 alone will not fully resolve anemia, which is why comprehensive blood work helps