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In the TME of PCa, prostate stromal cells, especially CAFs, secrete insulin-like growth factors (IGFs), thereby promoting extracellular matrix remodeling (Goel et al., 2006)

[DOI] [PubMed] [Google Scholar] Hamberg M

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Consequently, ERs may protect against joint degeneration through ferroptosis-related mechanisms, highlighting their potential as therapeutic targets for OA and other related diseases, such as mucopolysaccharidoses