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The mechanism is that the RNA methyltransferase METTL3 promotes the stability of SLC7A11 mRNA by targeting adenine (+ 1795) on SLC7A11 mRNA and reduces the ubiquitination of SLC7A11 protein

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Hu S, Chen B, Zhou J, Liu F, Mao T, Pathak JL, et al

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Reference Schapira, AHV 2006, Mitochondrial Disease, The Lancet , vol