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It is not yet clear how ALCAR exerts its protective effect in the brain, but potential hypotheses include improved neurotransmitter synthesis, or improved energy generation in neurons preventing their damage

Preclinical studies show that in hypothyroidism, reduced T3 availability suppresses AMPK activity, disinhibits mTOR, and diminishes autophagic flux, leading to impaired lipophagy and mitophagy (60, 61)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Gulewitsch W., Krimberg R

Journal of Orofacial Pain
