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Acknowledgements This study was partially supported by (1) Grant-in-Aid for Scientific Research (C) of the Ministry of Culture and Science of Japan (20590810, 23591017, 24591020, 12008507, 17877850, 17K09468, 15K09052, 24591020, 15K09052, 18K0792, 121K07943), (2) the Research Program on Intractable Diseases, from the Ministry of Labor and Welfare of Japan, and (3) grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan, (4) the Research Program from the Japan Medical Research and Development (AMED) (17824893), and (5) The branding program as a world-leading research university on intractable immune and allergic diseases supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan

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