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CREB regulates gene expression of dynorphin, a protein that slows dopamine release, dampening the reward system

An instructive example might also be the counteracted effect of the cuprizone, a neurotoxin commonly used to produce multiple-sclerosis-like lesions in rats, attenuated brain lesions, and recovered muscle functions [80]

J Antimicrob Chemother

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It is a research compound that has not been approved for human use by the TGA
