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The backbone-cyclized ABLE protein ( CABLE ) was generated by connecting the C- and N-termini through engineered loop structures using the intein-mediated NCL of the expressed precursor (Fig

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Similar content being viewed by others Introduction Lynch Syndrome (LS) is an inherited heterozygous autosomal dominant disorder which predisposes affected individuals to the risk of developing colorectal cancer (CRC) as well as to endometrial carcinomas, tumours of the stomach, small intestines, ureter, brain, pelvis and prostate among others 1