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PEM is characterised by a delayed onset, prolonged duration, and an intensity disproportionate to the precipitating exertion (15, 16)

Second is the problem of tissue targeting

Differential roles of dihydropyridine calcium antagonist nifedipine, nitrendipine and amlodipine on gentamicin-induced renal tubular toxicity in rats

For dye-based DSF, SYPO Orange (Sigma-Aldrich) was used at a dilution of 1:1000 with a protein concentration 0.1 mg/mL in a final volume of 25 L

C.YangJ.et al

"An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria"