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Intramuscular injection delivers B12 directly into tissue, which is critical for patients whose digestive systems cannot absorb oral supplements effectively

P=0.022), which were still both significantly lower than that of the control group

A B12 shot is a quick intramuscular injection of vitamin B12 (cobalamin) that bypasses the stomach acid, liver metabolism, and intestinal absorption issues that limit oral B12 to roughly 1% bioavailability in most adults

Abbott) [13], and urine concentrations of MMA by gas chromatographymass spectrometry [14, 15]

However, women who are pregnant, breastfeeding, or planning pregnancy should avoid 5-amino-1MQ due to insufficient safety data

For those with neurological symptoms, hydroxocobalamin 1 mg is given on alternate days until no further improvement is observed, as recommended by NICE guidance and the product information