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All of these versions of the model were fitted, and the estimated protective levels were very similar (Extended Data Fig

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Specifically, we hypothesize that for antioxidants taken for the purpose of targeting and protecting the brain (as is the case of NAC for schizophrenia), maximal therapeutic efficacy will occur when the antioxidant is administered at a time and in a manner that delivers the antioxidant to the brain when sleep need is highest, at sleep onset

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