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Description
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PMCID: PMC9655540
During ageing and in many chronic conditions, cells in our body lose the capacity to make enough Glyteine to maintain sufficient levels of cellular glutathione to fight off oxidative stress
NAPDH Oxidase converts oxygen to Super Oxide (O 2 ) mainly in neutrophils Myeloperoxidase (MPO) converts peroxide (H2O2) into Hydrochloric Acid (HOCl) mainly in neutrophils Fenton Reaction generates Hydroxide (OH-) from peroxide (H2O2) using iron Superoxide Dismutase (SOD) converts Super Oxide (O 2 ) to peroxide (H2O2) Glutathione convert Hydroxide (OH-) to water Catalase converts Peroxide (H2O2) to water We will see in the immunology section that that a defect in NADPH Oxidase causes Chronic Granulomatous disease
The structural changes of the NBD dimer regulate the ion fluxes trough the gateway
Cancer 24, 825
