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The presence of the D1236 (from MRP2 substitution) instead of G1228 (wild-type MRP1) in the chimera M8 could create a steric hindrance, as shown by the Cryo-EM apo and LTC 4 bound (inward-facing) structures of bovine MRP1 40,44 (Fig

Antioxidative and hepatoprotective effects of magnolol on acetaminophen-induced liver damage in rats

217 This promotes the migration of myeloperoxidase (MPO) and neutrophil elastase (NE) to the nuclear envelope, where NE partially degrades histones, leading to chromatin decondensation and the release of neutrophil extracellular traps (NETs)

(1999) J Mol Biol 291 : 913 PubMed: 10452896 Search on PubMed DOI: Primary Citation Related Structures: 12GS, 13GS, 18GS, 19GS, 20GS PubMed Abstract: Glutathione S -transferases (GSTs) play a pivotal role in the detoxification of foreign chemicals and toxic metabolites

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